Cyclophosphamide is an alkylating drug indicated for treatment of. For information on carcinogenicity, go here and then scroll down to cyclophosphamide to download a pdf file on this chemical. Although women taking cyclophosphamide can stop having periods, they can still become pregnant, so an effective form of birth control to prevent pregnancy should be used while taking this medication since cyclophosphamide can cause fetal harm. Lyophilized cytoxan cyclophosphamide for injection, usp. Highlights of prescribing information these highlights do not include all the information needed to use votrient safely and effectively. Cyclophosphamide is soluble in water, saline, or ethanol. Although the protocol allowed further therapy, only 15% received both drugs for 9 or more courses. Cyclophosphamide interferes with oogenesis and spermatogenesis. Learn about benlysta belimumab, an fdaapproved prescription infusion or selfinjectable lupus medication to help treat your request your free info kit.
Cytoxan tablets cyclophosphamide tablets, usp are for oral use and contain 25 mg or 50 mg cyclophosphamide. A few of the types of cancer that it may be used to treat include leukemia, ovarian cancer, and lymphomas. Cyclophosphamide should only be administered where there are facilities for regular monitoring of clinical, biochemical and haematological parameters before, during, and after administration and under the direction of a specialist oncology service. During or immediately after the administration, adequate amounts of fluid should be ingested or infused to force diuresis to reduce the risk of urinary tract. Rydapt midostaurin capsules, for oral use initial u. Leukemias see also dosage and administration a chronic lymphocytic leukemia cll rai stages ii, iii, iv binet stages b, cnote. Administer a lymphodepleting regimen of cyclophosphamide and fludarabine before infusion of yescarta 2. Cyclophosphamide is indicated for the treatment of biopsy proven minimal change nephrotic syndrome in. Get a printable copy pdf file of the complete article 251k, or click on a page image below to browse page by page. Package insert thiotepa for injection, usp description thiotepa for injection is an ethyleniminetype compound. The recommended duration of treatment for patients previously untreated with ribavirin and interferon is 24 to 48 weeks.
Cyclophosphamide fda prescribing information, side. The medicine works by crosslinking dna cells and suppressing the immune system. List of drug master files dmf of cyclophosphamide active pharmaceutical ingredient api submitted to the u. Cyclophosphamide has also been used as a single agent in the treatment of lowgrade lymphomas. The length of treatment depends on the types of drugs you are taking, how well your body responds to them, and the type of cancer or condition you have. There is positive evidence of human fetal risk, but the benefits from use. Tap along the timeline to move to different parts of the audio file. When given with kisqali, refer to the full prescribing information for the recommended dose of the aromatase inhibitor being used. Its prescribed for nonhodgkin lymphoma, hodgkin lymphoma, multiple.
In a study conducted by the gynecological oncology group gog, 410 patients with stage iii or iv disease 1 cm residual disease after staging. Dailymed cyclophosphamide injection, powder, for solution. It is eliminated primarily in the form of metabolites. Lyra study article pdf available in british journal of haematology 1853 march. Full text full text is available as a scanned copy of the original print version. Highlights of prescribing information these highlights do not. Cyclophosphamide induced sterility may be irreversible in some patients. Commence infusion in the morning, so that frequent voiding occurs and cyclophosphamide metabolites do not rest in the bladder for prolonged periods. Cytoxan tablets cyclophosphamide tablets, usp are for oral use and contain 25 mg or 50 mg cyclophosphamide anhydrous. These highlights do not include all the information needed to use advate safely and effectively. Cyclophosphamide cyc is an alkylating agent that was introduced into clinical practice as a chemotherapeutic agent but has also been used to treat a number of systemic autoimmune diseases. Cyclophosphamide fda prescribing information, side effects. Cyclophosphamide is well absorbed after oral administration with a bioavailability greater than 75%.
Contraindications known hypersensitivity to the active substance. Cyclophosphamide can be recommended for use in treatment of. Take cyclophosphamide at around the same time every day. When given with kisqali, the recommended dose of fulvestrant is 500 mg administered on days 1, 15, 29, and once monthly thereafter. See full prescribing information for herceptin hylecta. It is supplied as a nonpyrogenic, sterile lyophilized powder for intravenous, intracavitary or intravesical administration, containing 15 mg and 30 mg of thiotepa. Cyclophosphamide has a molecular formula of c 7 h 15 cl 2 n 2 o 2 ph 2 o and a molecular weight of 279.
Your doctor will check that the number of red blood cells, white blood cells and platelets is high enough before and during your treatment with cyclophosphamide. Drug name mechanism of action and pharmacokinetics indications and status adverse effects dosing. Herceptin hylecta trastuzumab and hyaluronidaseoysk injection, for subcutaneous use initial u. Highlights of prescribing information the recommended dose. Cyclophosphamide is the generic name of the prescription drug cytoxan, a chemotherapy drug for people with certain cancers.
Information for the patient mock up cyclophosphamide 50 mg tablets by caroline mcdermott at this product is available as the above name but will be referred to as cyclophosphamide throughout the following leaflet. Rituxan rituximab is indicated, in combination with fludarabine and cyclophosphamide fc, for the treatment of patients with previously untreated and previously treated cd20positive cll. Cyclophosphamide is used to treat various types of cancer. Definition from the nci drug dictionary detailed scientific definition and other names for this drug.
Dec 14, 2016 cyclophosphamide tablets are for oral use. Cyclophosphamide, although effective alone in susceptible malignancies, is more frequently used concurrently or sequentially with other antineoplastic drugs. Cyclophosphamide for injection, usp is a sterile white cake available as 500 mg, 1 g, and 2 g strength vials. Please refer to the full prescribing information of fulvestrant. Sandoz launches first generic version of cyclophosphamide. Cyclophosphamide, also called cytoxan, is classified as a cytotoxic agent, because it has a toxic effect on many types of cells good cells as well as bad. Rheumatoid arthritis ra rituxan rituximab in combination with methotrexate is indicated for the treatment of adult.
The unchanged drug has an elimination halflife of 3 to 12 hours. If you need help accessing information in different file formats. Cyclophosphamide tablets, usp are for oral use and contain 25 mg or 50 mg cyclophosphamide anhydrous. Cyclophosphamide is also being studied in the treatment of other types of cancer. Only select registry of toxic effects of chemical substances rtecs data is presented here. Sep 17, 2019 cyclophosphamide has a molecular formula c 7 h 15 cl 2 n 2 o 2 p h 2 o and a molecular weight of 279. Cytoxan cyclophosphamide for injection, usp cytoxan.
Highlights of prescribing information these highlights do not include all the information needed to use herceptin hylecta safely and effectively. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for cytoxan cyclophosphamide skip to. Cyclophosphamide monohydrate c7397 product information sheet. Thiotepa is a synthetic product with antitumor activity. Cyclophosphamide for injection, usp is a sterile white powder containing cyclophosphamide and is supplied in vials for single dose use. Cyclophosphamide is commonly used with doxorubicin hydroxydaunorubicin, vincristine oncovin, and prednisone known as the chop regimen, with or without other agents, in the treatment of various types of intermediategrade nonhodgkin lymphoma.
Isoniazid tablets usp national institutes of health. The lowest goodrx price for the most common version of cyclophosphamide is. Discontinue doxorubicin hydrochloride in patients who develop signs or symptoms of cardiomyopathy 2. Medscape prescription drug monographs are based on fdaapproved labeling. Based on mechanism of action and published reports of effects in pregnant patients or animals, drug can cause fetal harm when. Medscape indicationspecific dosing for cytoxan cyclophosphamide. Cyclophosphamide is soluble in water, saline and ethanol. Cyclophosphamide is used alone or in combination with other medications to treat hodgkins lymphoma hodgkins disease and nonhodgkins lymphoma types of cancer that begin in a type of white blood cells that normally fights infection.
Multiple myelomas myeloma stages ii, iiia, iiib see also dosage and. Pegasys package insert for all instructions regarding pegasys dosing and administration. Cyclophosphamide is a cytotoxic drug for the treatment of malignant disease in. Intravenous cyclophosphamide for renal patients protocol. Multiple myelomas myeloma stages ii, iiia, iiib see also dosage and administration 3. Federal usa law restricts this drug to use by or on the order of a licensed veterinarian. Cytoxan cyclophosphamide dosing, indications, interactions. Oct 08, 2019 cyclophosphamide interferes with oogenesis and spermatogenesis. Cyclophosphamide for injection, usp ndc 1001995501 500 mg vial, carton of 1 ndc 1001995601. The contents are intended for use in a pharmacy admixture program and are restricted to the preparation of admixtures for intravenous infusion. The molecular formula is c7h15cl2n2o2p and its molecular weight is 261. Medlineplus information on cyclophosphamide a lay language summary of important information about this drug that may include the. Cytoxan cyclophosphamide for injection, usp cytoxan tablets cyclophosphamide tablets, usp description cytoxan cyclophosphamide for injection, usp is a sterile white powder containing cyclophosphamide mono hydrate.
This medicine is used to treat many types of cancer like lymphoma, myeloma, leukemia, breast cancer, and ovarian cancer, to name a few. Anthracyclines including doxorubicin should not be administered in combination with other cardiotoxic agents unless the patients cardiac function is closely monitored. Cyclophosphamide monohydrate cas 6055192 calbiochem empirical formula hill notation. See actual entry in rtecs for complete information. The recommended dosage and schedule in combination with fludarabine and cyclophosphamide is. Votrient pazopanib tablets, for oral use initial u. Cyclophosphamide also works by decreasing your immune systems. Cyclophosphamide is a known teratogen with significant limb abnormalities and cognitive impairment resulting from firsttrimester exposure. Caution should be used when treating patients with cyclophosphamide who have preexisting heart disease. Sections or subsections omitted from the full prescribing information. When protected from light and stored at 5 c the loss was 0. Cyclophosphamide for injection, usp, is a chemotherapy agent used to treat certain types of.
Cyclophosphamide comes as a tablet to take by mouth once a day. Sandoz is launching cyclophosphamide injection, usp, through collaboration with jiangsu hengrui medicine co. Read all of this leaflet carefully before you start taking this medicine because it contains important information. Daratumumab, bortezomib, cyclophosphamide and dexamethasone in newly diagnosed and relapsed multiple myeloma. A pharmacy bulk package is a container of a sterile preparation for parenteral use that contains many single doses. Ribavirin ribavirin tablet, film coated aurobindo pharma. Jun, 20 cyclophosphamide has a molecular formula of c 7 h 15 cl 2 n 2 o 2 ph 2 o and a molecular weight of 279.
Tc can be given either before breast cancer surgery neoadjuvant to shrink the size of the tumor, or after surgery adjuvant to kill any cancer cells that may be still present in the body. Hepatotoxicity see full prescribing information for complete boxed warning. Patients receiving anthracyclines after stopping treatment with other cardiotoxic agents. Highlights of prescribing information these highlights do not include all the information needed to use rydapt safely and effectively. Cyclophosphamide for injection, usp, is a chemotherapy agent used to treat certain types of cancer in adults and pediatric patients. Cyclophosphamide hydrate investigated as a drug, mutagen, natural product, primary irritant, reproductive effector, and tumorigen. Cyclophosphamide is a prescription medicine that is licensed to treat certain kidney problems in children and various types of cancer. Cytoxan is an alkylating agent that forms covalent bonds with the building blocks of dna. Dose of cyclophosphamide may need to be adjusted according to renal function decline or recovery. Cyclophosphamide is a white crystalline powder with the molecular formula c 7 h 15 cl 2 n 2 o 2 p h 2 o and a molecular weight of 279. Ifosfamide is a white crystalline powder that is soluble in water. Farber cancer institute last revised 22018 patient and family education committee 4. Cytoxan cyclophosphamide for injection, usp cytoxan tablets. The chemical name for cyclophosphamide is 2 h1,3,2oxazaphosphorin2amine, n,nbis2chloroethyltetrahydro, 2oxide, monohydrate.
Isoniazid tablets usp rx only warning severe and sometimes fatal hepatitis associated with isoniazid therapy has been reported and may occur or may develop even after many months of treatment. Since cyclophosphamide is excreted in the urine, dosage adjustment may. Each capsule for oral administration contains 25 mg or 50 mg cyclophosphamide anhydrous, usp and the following inactive ingredients. Cyclophosphamide does not contain any antimicrobial preservative and thus care must be taken to assure the sterility of prepared solutions. Nails usually return to normal after treatment is finished. It is a chemotherapy drug that works by slowing or stopping cell growth.
Dailymed doxorubicin hydrochloride injection, powder. Cyclophosphamide is one of a number of medications first developed as a chemotherapy drug a medication used in the treatment of cancer. Dosage may be reduced, delayed or discontinued in patients with bone. Cytarabine injection, an antineoplastic, is a sterile solution of cytarabine for intravenous and subcutaneous use which contains no preservative and is available in 20 mgml mg50 ml pharmacy bulk package. Cytoxan is both a carcinogen and a tetrotogen causes birth defects. Chronic lymphocytic leukemias are considered to be a heterogenous group of chronic bcell disorders. Cyclophosphamide should only be used by clinicians experienced in the use of cancer chemotherapy. Inactive ingredients in cyclophosphamide tablets are. Summary of product characteristics ucl cancer trials centre. A guide to the dosage regimens used for most indications is given below. Cyclophosphamide has a molecular formula c 7 h 15 cl 2 n 2 o 2 p h 2 o and a molecular weight of 279. A cyclophosphamide dose reduction or omission may be required if leukopenic iii. Development of sterility appears to depend on the dose of cyclophosphamide, duration of therapy, and the state of gonadal function at the time of treatment.
These highlights do not include all the information needed to use cuvitru safely and effectively. Cyclophosphamide for injection, usp is a sterile white powder containing cyclophosphamide monohydrate. Cyclophosphamide is a synthetic antineoplastic drug chemically related to the nitrogen mustards. Follow the directions on your prescription label carefully, and ask your. It is also used to treat nephrotic syndrome in children. Ifosfamide is 32chloroethyl22chloroethyl aminotetrahydro2h1,3,2oxazaphosphorine 2oxide. Apr 08, 2019 belimumab package insert pdf belimumab has been studied in a limited number of sle patients with renal syringe are provided at the end of the package leaflet see stepbystep.
Toxic deaths, hepatotoxicity, neutropenia, hypersensitivity reactions, and fluid retention see full. Cyclophosphamide can cause infertility in both men and women. Purchase cyclophosphamide assistance snap purchase cyclophosphamide helps eligible lowincome ohioans stretch their food budgets and buy healthy food. Desferal is not indicated for the treatment of primary hemochromatosis, since phlebotomy is the method of choice for removing excess iron in this disorder.
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